According to previous literature, only a quarter of the dengue-infected patients will have primarily self-limiting symptoms. Most dengue-infected patients present with asymptomatic or inapparent infections. The economic costs associated with dengue were primarily attributed to hospitalization expenses and the loss of productivity due to deaths occurring during epidemic years. In Taiwan, the burden of dengue was substantial, resulting in an annual loss of 115.3 disability-adjusted life-years (DALYs) per million population. It is estimated there are 390 million dengue infections around the world yearly. The disease is transmitted by vectors such as Aedes aegypti carrying dengue virus (DENV). This meta-analysis revealed that overweight could be a clinical predictor for severe disease for pediatric patients with dengue infection.ĭengue fever is one of the most common arthropod-borne diseases around the globe. Our analysis results showed that patient with obesity is 50% (OR = 1.50 95%CI: 1.15–1.97) more likely to develop severe manifestation of dengue. In contrast, three cohort studies, three case-control studies, and one cross-sectional study reported no significant relationship between obesity and dengue severity. Three cohort studies, four case-control studies, and one cross-sectional studies found a significant association between obesity and dengue severity. Included patients in most studies were hospitalized pediatric patients. ResultsĪ total of 15 article involving a total of 6,508 patients were included in the meta-analysis. Mantel-Haenszel method and random effects model was used to analyze the pooled odds ratio with 95% confidence intervals. The two main keywords were “dengue” and “obesity”. MethodsĪ literature search for relevant studies was conducted in PubMed, Embase, Ovid Medline and Cochrane from inception to September 9, 2022. Here, we aimed to conduct a systematic review and meta-analysis to investigate the association between obesity and dengue severity. However, a firm conclusion could not be drawn due to the varied results of these studies.

Several studies have suggested that obese patients with dengue infection tend to have more severe manifestations with poorer prognosis. Obesity is known to deteriorate many infectious diseases due to impaired immune responses. Severe dengue often leads to poor clinical outcomes and high mortality as a result, it is of vital importance to find prognostic factors associated with the severe form of dengue.

System shock 3 poster